"What is glaucoma?” “What causes glaucoma?” “How do you treat glaucoma?” Patients, family members, and/or friends usually ask one (or all) of these questions. Because patients need to both understand and buy into the seriousness of the disease to comply with treatment and follow-up appointments, the optometrist must deliver simple answers.
What is glaucoma?
“Simply, glaucoma is nerve damage. Specifically, glaucoma is characteristic structural damage to the optic nerve,1-15 which communicates images from the retina to the brain. Glaucoma results in eventual associated correlating and irreversible defects in one’s field of vision.15-19 The condition is chronic, unstable, and progressive, so it must be monitored closely, tested frequently,20-23 and treated
sufficiently.25-33”
What causes glaucoma?
“Glaucoma may be caused by abnormal eye pressures, which are unique to each patient.33-39 Eye pressure is a measurement of the fluid within the eyes. Additionally, poor circulation to the eye or biochemical changes within the body may lead to characteristic structural damage to the optic nerve,1-15 with eventual associated correlating and irreversible defects to one’s visual field.15-19”
How is glaucoma treated?
“The best way to treat glaucoma is to lower abnormal eye pressures through prescription eye drops, laser procedures, and/or surgeries – whichever treatment is most effective, tolerable, and
sustainable for the patient.24, 26-28, 35, 37, 39 Additionally, we are learning that lifestyle40 makes a difference in both the diagnosis and prognosis of glaucoma. Therefore, eating healthy.41-45 staying active,46 not smoking,47-50 limiting stress through mindfulness/meditation,39, 51-52 preventing poor circulation from blood pressure that may be too low or too high,47,54-62 and treating risk factors, such as sleep apnea 47,63,64 may also help prevent or slow progressive glaucomatous damage.”
A bonus question
Occasionally, a patient asks me why I have a particular interest in glaucoma. I am happy to reply that I find the disease to be both challenging and rewarding. It is continually challenging trying to better understand why glaucoma develops in some individuals, determining who/when to treat, and ever-refining how to provide effective, tolerable, and sustainable treatment over the course of their disease. Furthermore, from the time of diagnosis, this chronic, unstable, and progressive disease is associated with both short-term and long-term decisions, which must be made at every visit. These decisions, in turn, directly affect (hopefully positively) visual prognosis years down the road. It is rewarding (when possible) to help prevent functional vision loss by diagnosing glaucoma earlier and detecting progression sooner. OM
References
1. Jonas JB, Budde WM, Panda-Jonas S. Ophthalmoscopic evaluation of the optic nerve head. Surv Ophthalmol. 1999;43(4):293–320.2. doi: 10.1016/s0039-6257(98)00049-6.
2. Fingeret M, Medeiros FA, Susanna R Jr, Weinreb RN. Five rules to evaluate the optic disc and retinal nerve fiber layer for glaucoma. Optometry. 2005;76(11):661–668.3. doi: 10.1016/j.optm.2005.08.029.
3. Choudhari NS, Neog A, Fudnawala V, George R. Cupped disc with normal intraocular pressure: the long road to avoid misdiagnosis. Indian J Ophthalmol. 2011;59(6):491–497. doi: 10.4103/0301-4738.86320.
4. Gandhi M, Dubey S. Evaluation of the Optic Nerve Head in Glaucoma. J Curr Glaucoma Pract. 2013;7(3):106–114. doi: 10.5005/jp-journals-10008-1146.
5. Jonas JB, Bergua A, Schmitz-Valckenberg P, Papastathopoulos KI, Budde WM. Ranking of optic disc variables for detection of glaucomatous optic nerve damage. Invest Ophthalmol Vis Sci. 2000;41(7):1764–1773.
6. Susanna R Jr, Vessani RM. New findings in the evaluation of the optic disc in glaucoma diagnosis. Curr Opin Ophthalmol. 2007;18(2):122–128.7. doi: 10.1097/ICU.0b013e328040bfe0.
7. Skaat A, De Moraes CG, Bowd C, et al. African Descent and Glaucoma Evaluation Study (ADAGES): Racial Differences in Optic Disc Hemorrhage and Beta-Zone Parapapillary Atrophy. Ophthalmology. 2016;123(7):1476–1483. doi: 10.1016/j.ophtha.2016.03.025.
8. O’Neill EC, Gurria LU, Pandav SS, et al. Glaucomatous Optic Neuropathy Evaluation Project: Factors Associated With Underestimation of Glaucoma Likelihood. JAMA Ophthalmol. 2014;132(5):560–566. doi: 10.1001/jamaophthalmol.2014.96.
9. Greenfield, DS, Siatkowski RM, Glaser JS, Schatz NJ, Parrish RK. The cupped disc: Who needs neuroimaging? Ophthalmology. 1998;105(10):1866-74. doi: 10.1016/S0161-6420(98)91031-4.
10. Spaeth GL, Henderer J, Liu C, et al. The disc damage likelihood scale: reproducibility of a new method of estimating the amount of optic nerve damage caused by glaucoma. Trans Am Ophthalmol Soc. 2002;100:181–186.
11. Dias DT, Ushida M, Battistella R, Dorairaj S, Prata TS. Neurophthalmological conditions mimicking glaucomatous optic neuropathy: analysis of the most common causes of misdiagnosis. BMC Ophthalmol. 2017;17(1):2. doi: 10.1186/s12886-016-0395-x.
12. Zangalli C, Gupta SR, Spaeth GL. The disc as the basis of treatment for glaucoma. Saudi J Ophthalmol. 2011;25(4):381–387. doi: 10.1016/j.sjopt.2011.07.003.
13. Tan NYQ, Sng CCA, Jonas JB, Wong TY, Jansonius NM, Ang M. Glaucoma in myopia: diagnostic dilemmas. Br J Ophthalmol. 2019;103(10):1347‐1355. doi: 10.1136/bjophthalmol-2018-313530.
14. Shon K, Hye Jo Y, Won Shin J, Kwon J, Jeong D, Kook MS. Nasalization of Central Retinal Vessel Trunk Predicts Rapid Progression of Central Visual Field in Open-Angle Glaucoma. Sci Rep. 2020;10(1):3789. doi: 10.1038/s41598-020-60355-1.
15. Weinreb RN, Aung T, Medeiros FA. The pathophysiology and treatment of glaucoma: a review. JAMA. 2014;311(18):1901-11. doi: 10.1001/jama.2014.3192.
16. Khoury JM, Donahue SP, Lavin PJ, Tsai JC. Comparison of 24-2 and 30-2 perimetry in glaucomatous and nonglaucomatous optic neuropathies. J Neuroophthalmol. 1999;19(2):100-8.
17. Keltner JL, Johnson CA, Cello KE, et al. Classification of Visual Field Abnormalities in the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2003;121(5):643–650. doi: 10.1001/archopht.121.5.643.
18. Ng M, Sample PA, Pascual JP, et al. Comparison of visual field severity classification systems for glaucoma. J Glaucoma. 2012;21(8):551–56. doi: 10.1097/IJG.0b013e31821dac66.
19. Keltner JL, Johnson CA, Levine RA, et al. Normal visual field test results following glaucomatous visual field end points in the Ocular Hypertension Treatment Study. Arch Ophthalmol. 2005;123(9):1201–1206. doi: 10.1001/archopht.123.9.1201.
20. Fung SSM, Lemer C, Russell RA, Malik R, Crabb DP. Are practical recommendations practiced? A national multi-centre cross-sectional study on frequency of visual field testing in glaucoma. Br J Ophthalmol. 2013;97(7):843-7. doi: 10.1136/bjophthalmol-2012-302903.
21. Chauhan BC, Garway-Heath DF, Goñi FJ, et al. Practical recommendations for measuring rates of visual field change in glaucoma. Br J Ophthalmol. 2008;92(4):569–573. doi: 10.1136/bjo.2007.135012.
22. Hood DC, De Moraes CG. Four Questions for Every Clinician Diagnosing and Monitoring Glaucoma. J Glaucoma. 2018;27(8):657–664. doi: 10.1097/IJG.0000000000001010.
23. Hood DC. Improving our understanding, and detection, of glaucomatous damage: An approach based upon optical coherence tomography (OCT). Prog Retin Eye Res. 2017;57:46–75. doi: 10.1016/j.preteyeres.2016.12.002.
24. European Glaucoma Society Terminology and Guidelines for Glaucoma, 4th Edition - Chapter 3: Treatment principles and options Supported by the EGS Foundation: Part 1: Foreword; Introduction; Glossary; Chapter 3 Treatment principles and options. Br J Ophthalmol. 2017;101(6):130–195. doi: 10.1136/bjophthalmol-2016-EGSguideline.003.
25. Sihota R, Angmo D, Ramaswamy D, Dada T. Simplifying "target" intraocular pressure for different stages of primary open-angle glaucoma and primary angle-closure glaucoma. Indian J Ophthalmol. 2018;66(4):495–505. doi: 10.4103/ijo.IJO_1130_17.
26. Wesselink C, Stoutenbeek R, Jansonius NM. Incorporating life expectancy in glaucoma care. Eye (Lond). 2011;25(12):1575–1580. doi: 10.1038/eye.2011.213.
27. Cohen LP, Pasquale LR. Clinical characteristics and current treatment of glaucoma. Cold Spring Harb Perspect Med. 2014;4(6):a017236. doi: 10.1101/cshperspect.a017236.
28. Parikh RS, Parikh SR, Navin S, Arun E, Thomas R. Practical approach to medical management of glaucoma. Indian J Ophthalmol. 2008;56(3):223–230. doi: 10.4103/0301-4738.40362.
29. Jay JL, Murdoch JR. The rate of visual field loss in untreated primary open angle glaucoma. Br J Ophthalmol. 1993;77(3):176–178. doi: 10.1136/bjo.77.3.176.
30. Heijl A. The times they are a-changin': time to change glaucoma management. Acta Ophthalmol. 2013;91(1):92–99. doi: 10.1111/j.1755-3768.2011.02328.x.
31. Susanna R Jr, De Moraes CG, Cioffi GA, Ritch R. Why Do People (Still) Go Blind from Glaucoma?. Transl Vis Sci Technol. 2015;4(2):1. doi: 10.1167/tvst.4.2.1.
32. Kastner A, King AJ. Advanced glaucoma at diagnosis: current perspectives. Eye (Lond). 2020;34(1):116-128. doi: 10.1038/s41433-019-0637-2.
33. Kass MA, Heuer DK, Higginbotham EJ, et al. The Ocular Hypertension Treatment Study: a randomized trial determines that topical ocular hypotensive medication delays or prevents the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002;120(6):701–830. doi: 10.1001/archopht.120.6.701.
34. Miglior S, Zeyen T., Pfeiffer N, et al. Results of the European Glaucoma Prevention Study. Ophthalmology. 2005;112:366-375. doi: 10.1016/j.ophtha.2004.11.030.
35. Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M. Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol. 2002;120(10):1268–1279. doi: 10.1001/archopht.120.10.1268.
36. Musch DC, Gillespie BW, Niziol LM, Lichter PR, Varma R; CIGTS Study Group. Intraocular pressure control and long-term visual field loss in the Collaborative Initial Glaucoma Treatment Study. Ophthalmology. 2011;118(9):1766–1773. doi: 10.1016/j.ophtha.2011.01.047.
37. The Advanced Glaucoma Intervention Study (AGIS): 7. The relationship between control of intraocular pressure and visual field deterioration. The AGIS Investigators. Am J Ophthalmol. 2000;130(4):429-440. doi: 10.1016/s0002-9394(00)00538-9.
38. Sommer A, Tielsch JM, Katz J, et al. Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore Eye Survey. Arch Ophthalmol. 1991;109:1090-1095. doi: 10.1001/archopht.1991.01080080050026.
39. Comparison of glaucomatous progression between untreated patients with normal-tension glaucoma and patients with therapeutically reduced intraocular pressures. Collaborative Normal-Tension Glaucoma Study Group. Am J Ophthalmol. 1998;26:487-497. doi: 10.1016/s0002-9394(98)00223-2.
40. Dada T, Verma S, Gagrani M, et al. Ocular and Systemic Factors Associated with Glaucoma. J Curr Glaucoma Pract. 2022;16(3):179-191. doi: 10.5005/jp-journals-10078-1383.
41. Tribble JR, Hui F, Jöe M, et al. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells. 2021;10(2):295. doi: 10.3390/cells10020295.
42. Kang JH, Pasquale LR, Willett W, et al. Antioxidant intake and primary open-angle glaucoma: a prospective study. Am J Epidemiol. 2003;158(4):337-46. doi: 10.1093/aje/kwg167.
43. Ramdas WD, Schouten JSAG, Webers CAB. The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis. Nutrients. 2018;10(3):359. doi: 10.3390/nu10030359.
44. Adornetto A, Rombolà L, Morrone LA, et al. Natural Products: Evidence for Neuroprotection to Be Exploited in Glaucoma. Nutrients. 2020;12(10):3158. doi: 10.3390/nu12103158.
45. Ramdas WD. The relation between dietary intake and glaucoma: a systematic review. Acta Ophthalmol. 2018;96(6):550-556. doi: 10.1111/aos.13662.
46. Tribble JR, Hui F, Jöe M, et al. Targeting Diet and Exercise for Neuroprotection and Neurorecovery in Glaucoma. Cells. 2021;10(2):295. doi:10.3390/cells10020295.
47. McMonnies CW. Glaucoma history and risk factors. J Optom. 2017;10(2):71-78. doi: 10.1016/j.optom.2016.02.003.
48. Jain V, Jain M, Abdull MM, Bastawrous A. The association between cigarette smoking and primary open-angle glaucoma: a systematic review. Int Ophthalmol. 2017;37(1):291-301. doi: 10.1007/s10792-016-0245-0.
49. Nishida T, Mahmoudinezhad G, Weinreb RN, et al. Smoking and progressive retinal nerve fibre layer thinning in glaucoma. Br J Ophthalmol. 2023 Nov;107(11):1658-1664. doi: 10.1136/bjo-2022-321237.
50. Lee CS, Owen JP, Yanagihara RT, et al. Smoking Is Associated with Higher Intraocular Pressure Regardless of Glaucoma: A Retrospective Study of 12.5 Million Patients Using the Intelligent Research in Sight (IRIS) Registry. Ophthalmol Glaucoma. 2020;3(4):253-261. doi: 10.1016/j.ogla.2020.03.008.
51. Dada T, Gagrani M. Mindfulness Meditation Can Benefit Glaucoma Patients. J Curr Glaucoma Pract. 2019;13(1):1-2. doi: 10.5005/jp-journals-10078-1239. Note: See Reference for helpful flowchart.
52. Dada T, Mittal D, Mohanty K, et al. Mindfulness Meditation Reduces Intraocular Pressure, Lowers Stress Biomarkers and Modulates Gene Expression in Glaucoma: A Randomized Controlled Trial. J Glaucoma. 2018;(12):1061-1067. doi: 10.1097/IJG.0000000000001088.
53. Dada T, Mondal S, Midha N, et al. Effect of Mindfulness-Based Stress Reduction on Intraocular Pressure in Patients With Ocular Hypertension: A Randomized Control Trial. Am J Ophthalmol. 2022;239:66-73. doi: 10.1016/j.ajo.2022.01.017.
54. Leeman M, Kestelyn P. Glaucoma and Blood Pressure. Hypertension. 2019;73(5):944-950. doi: 10.1161/HYPERTENSIONAHA.118.11507.
55. Zhao D, Cho J, Kim MH, Guallar E. The association of blood pressure and primary open-angle glaucoma: a meta-analysis. Am J Ophthalmol. 2014;158(3):615-27.e9. doi: 10.1016/j.ajo.2014.05.029.
56. Kim H, Choi B. Nonlinear Relationship Between Blood Pressure and Glaucoma in US Adults. Am J Hypertens. 2019;32(3):308-316. doi: 10.1093/ajh/hpy186.
57. Leske MC, Wu SY, Hennis A., Honkanen R., Nemesure B. BESs Study Group. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology.2008;115(1):85-93. doi: 10.1016/j.ophtha.2007.03.017.
58. Costa VP, Harris A, Anderson D, et al. Ocular perfusion pressure in glaucoma. Acta Ophthalmol. 2014;92(4):e252-66. doi: 10.1111/aos.12298.
59. Bowe A, Grünig M, Schubert J, et al. Circadian Variation in Arterial Blood Pressure and Glaucomatous Optic Neuropathy—A Systematic Review and Meta-Analysis. Am J Hypertens.2015;28(9):1077-82. doi: 10.1093/ajh/hpv016.
60. Topouzis F, Coleman AL, Harris A, et al. Association of blood pressure status with the optic disk structure in non-glaucoma subjects: the Thessaloniki Eye Study. Am J Ophthalmol. 2006;142(1):60-67. doi: 10.1016/j.ajo.2006.02.055.
61. Bonomi L., Marchini G, Marraffa, Bernardi P, Morbio R, Varotto A. Vascular risk factors for primary open-angle glaucoma: the Egna-Neumarkt Study. Ophthalmology. 2000;107(7):1287-93. doi: 10.1016/s0161-6420(00)00138-x.
62. Macri C, Wong CX, Tu SJ, et al. Blood Pressure Measures and Incident Primary Open-Angle Glaucoma. Invest Ophthalmol Vis Sci. 2022;63(13):3. doi: 10.1167/iovs.63.13.3.
63. García-Sánchez A, Villalaín I, Asencio M, García J, García-Rio F. Sleep apnea and eye diseases: evidence of association and potential pathogenic mechanisms. J Clin Sleep Med. 2022;18(1):265-278.
64. Yu BE, Cheung R, Hutnik C, Malvankar-Mehta MS. Prevalence of Obstructive Sleep Apnea in Glaucoma Patients: A Systematic Review and Meta-analysis. J Curr Glaucoma Pract. 2021;15(3):109-116. doi: 10.5005/jp-journals-10078-1301.